Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells |
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Authors: | WP Benten M Lieberherr CE Sekeris F Wunderlich |
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Affiliation: | Humboldt-Universit?t zu Berlin, Institut für Biologie/Bakterienphysiologie, Germany. |
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Abstract: | MalK is the ATP-hydrolyzing subunit of the binding protein-dependent ATP-binding-cassette (ABC) transport system for maltose from Salmonella typhimurium. In a recent hypothesis, Glu64 and Glu94 of MalK were proposed as candidates for 'catalytic carboxylate', common to ATP- and GTP-hydrolyzing proteins [Yoshida and Amano (1995) FEBS Lett. 359, 1-5]. Substitution of both residues and, additionally, Glu74 by either glutamine or glycine and valine, respectively, had no deleterious effect on maltose transport. Thus, our data disprove the above notion. |
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