Low-power concentration and separation using temperature gradient focusing via Joule heating |
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Authors: | Kim Sun Min Sommer Greg J Burns Mark A Hasselbrink Ernest F |
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Affiliation: | Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA. sunmk@umich.edu |
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Abstract: | We present an experimental study of temperature gradient focusing (TGF) exploiting an inherent Joule heating phenomenon. A simple variable-width PDMS device delivers rapid and repeatable focusing of model analytes using significantly lower power than conventional TGF techniques. High electric potential applied to the device induces a temperature gradient within the microchannel due to the channel's variable width, and the temperature-dependent mobility of the analytes causes focusing at a specific location. The PDMS device also shows simultaneous separation and concentration capability of a mixture of two sample analytes in less than 10 min. An experiment combining Joule heating with external heating/cooling further supports the hypothesis that temperature is indeed the dominant factor in achieving focusing with this technique. |
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