| 巴洛沙星的生产新工艺 |
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| 引用本文： | 周勇,郝二军,李伟,徐桂清,胡志国. 巴洛沙星的生产新工艺[J]. 精细石油化工, 2008, 25(1): 56-59 |
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| 作者姓名： | 周勇 郝二军 李伟 徐桂清 胡志国 |
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| 作者单位： | 新乡学院化学与环境工程系,河南,新乡,453003;河南师范大学化学与环境科学学院,河南,新乡,453002 |
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| 摘 要： | 结合生产中的实际情况,对现有合成路线进行了优化设计,探索出了适合工业化生产的巴洛沙星的新工艺。用螯合法把化合物1-环丙基-6,7-二氟-1,4二氢-8-甲氧基-4-氧代-3-喹啉羧酸乙酯(DFQ-Et)螯合制得硼螯合物(1-环丙基-6,7-二氟-1,4二氢-8-甲氧基-4-氧代-3-喹啉羧硼二乙酯)[DFQ-B(OAc)_2],再与3-甲氨基哌啶缩合,水解得到巴洛沙星,总收率75.2%。并对巴洛沙星进行了结构表征,该工艺反应条件温和,原料易得,操作简便,产率高,成本较低,适合工业化生产。
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| 关 键 词： | 巴洛沙星 螯合法 抗菌剂 |
A NEW IMPROVED TECHNOLOGY FOR PRODUCTION OF BALOFLOXACIN |
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| Zhou Yong,Hao Erjun,Li Wei,Xu Guiqing,Hu Zhiguo. A NEW IMPROVED TECHNOLOGY FOR PRODUCTION OF BALOFLOXACIN[J]. Speciality Petrochemicals, 2008, 25(1): 56-59 |
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| Authors: | Zhou Yong Hao Erjun Li Wei Xu Guiqing Hu Zhiguo |
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| Abstract: | A novel route for the synthesis of balofloxacin from DFQ-B(OAc)_2 and 3-methylaminopipe- ridine was studied.The structure of the product identified was by IR,NMR.The total yield was 75.2%.Compared with the literature process,the improved method has the advantages of mild condi- tions,simple operation,easy isolation,high yield,safe and environmental benignity. |
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| Keywords: | balofloxacin production technology identification |
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