Endothelial vasodilatory function is predicted by circulating apolipoprotein B and HDL in healthy humans |
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Authors: | Steer Peter Hulthe Johannes Miligård Jonas Sarabi Dennis M Basu Samar Vessby Bengt Lind Lars |
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Affiliation: | (1) Department of Medical Sciences/Internal Medicine, University Hospital, SE-751 85 Uppsala, Sweden;(2) Department of Public Health and Caring Sciences/Geriatrics, University Hospital, SE-751 85 Uppsala, Sweden;(3) Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden |
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Abstract: | Endothelium-dependent vasodilation (EDV), LDL particle size, and antibodies against oxidized LDL (oxLDLab) have been shown
to be related to the development of atherosclerosis and cardiovascular disease. In this study, we investigated whether LDL
particle size, oxLDLab, apolipoproteins, and lipoproteins are related to endothelial vasodilatory function in a population
sample of 58 apparently healthy subjects aged 20 to 69 yr. EDV and endothelium-independent vasodilation (EIDV) were studied
in the forearm during local administration of methacholine chloride (2 and 4 μg/min) or sodium nitroprusside (5 and 10 μg/min).
Forearm blood flow was determined with venous occlusion plethysmography. In multiple stepwise regression analyses, neither
oxLDLab nor small LDL particles were significantly predictive of endothelial vasodilatory function. Instead, a high level
of apolipoprotein B (apoB) was an independent predictor of both attenuated EDV and EIDV (r=−0.43, P<0.01, and r=−0.34, P<0.05, respectively). HDL cholesterol, on the other hand, was the only lipid variable that was significantly related to the
EDV to EIDV ratio, an index of endothelial vasodilatory function (r=0.35, P<0.01). The inverse associations between apoB and both EDV and EIDV indicate that apoB might be an early marker of structural
vascular changes in healthy subjects, whereas HDL seems to be more specifically related to endothelial vasodilatory function. |
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