| 国产治疗用卡介苗预防浅表性膀胱癌术后复发及不良反应的观察 |
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| 引用本文： | 黄建,王国治,许纯兰,金杰.国产治疗用卡介苗预防浅表性膀胱癌术后复发及不良反应的观察[J].粉末涂料与涂装,2010,23(4). |
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| 作者姓名： | 黄建 王国治 许纯兰 金杰 |
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| 作者单位： | 黄建,王国治,许纯兰(中国药品生物制品检定所菌苗室,北京,100050);金杰(北京医科大学泌尿外科研究所,北京,100034) |
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| 摘 要： | 目的观察我国治疗用卡介苗(CT-BCG)预防浅表性膀胱癌术后复发情况及其不良反应。方法对117例浅表性膀胱癌患者术后给予CT-BCG治疗,另对53例患者采用丝裂霉素C(MI-C)治疗,作为对照。CT-BCG组每次用药120mg,MI-C组40mg。用导管灌注膀胱,2h后自行排出。术后2或3周开始,不同时间用药1次,直至1年。观察两组的复发情况及不良反应发生率。结果CT-BCG组复发率为18.8%,MI-C组为13.2%,二者差异无统计学意义;不良反应主要为膀胱炎症状(尿痛、尿频、血尿等)及低热,MI-C组无低热患者,且膀胱炎症状也较CT-BCG组轻。结论CT-BCG预防浅表性膀胱癌术后复发药效良好,无严重不良反应发生。
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| 关 键 词： | 治疗用卡介苗 浅表性膀胱癌 复发 不良反应 |
Clinical Trial of Effect and Adverse Reaction of Domestic Therapeutic BCG for Prevention of Recurrence of Superficial Bladder Cancer |
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| HUANG Jian,WANG Guo-zhi,XU Chun-lan,et al.Clinical Trial of Effect and Adverse Reaction of Domestic Therapeutic BCG for Prevention of Recurrence of Superficial Bladder Cancer[J].Chinese Journal of Biologicals,2010,23(4). |
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| Authors: | HUANG Jian WANG Guo-zhi XU Chun-lan |
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| Affiliation: | HUANG Jian,WANG Guo-zhi,XU Chun-lan,et al (National Institute for the Control of Pharmaceutical , Biological Products,Beijing 100050,China) |
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| Abstract: | Objective To observe the effect and adverse reaction of domestic therapeutic BCG, i.e. Chinese therapeutic BCG (CT-BCG)for prevention of recurrence of superficial bladder cancer. Methods A total of 117 patients with superficial bladder cancer after surgery were treated with 120 mg of CT-BCG, using 53 patients treated with 40 mg of milomycin-c (MI-C)as control. The CT-BCG and MI-C were infused into bladder through a vessel and excreted by the patients themselves 2 h later. The drugs were administered 2 or 3 ... |
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| Keywords: | Therapeutic BCG Superficial bladder cancer Recurrence Adverse reaction |
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