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| 采用HPLC方法测定氟伐他汀钠分散片的含量 | |
| 引用本文： | 刘郁,张念洁,刘连新,冷士良,孙婷婷.采用HPLC方法测定氟伐他汀钠分散片的含量[J].吉林化工学院学报,2011,28(1):23-25. |
| 作者姓名： | 刘郁 张念洁 刘连新 冷士良 孙婷婷 |
| 作者单位： | 1. 徐州工业职业技术学院,化学工程系,江苏,徐州,221140;中国矿业大学,化工学院,江苏,徐州,221008 2. 延边州技术监督局,检验所,吉林,延吉,133000 3. 徐州工业职业技术学院,化学工程系,江苏,徐州,221140 |
| 摘 要： | 目的:建立HPLC测定氟伐他汀钠分散片中氟伐他汀钠含量的方法.方法:色谱柱:THERMO C18(4.6 mm×250 mm,5μm),检测波长:305 nm,流量:1.2 mL.min-1,进样量:20μL,流动相:0.01 mol.L-1磷酸氢二钠(pH=3.0)-乙腈为40∶60.结果:氟伐他汀钠在0~100μg.mL-1范围内呈现良好的线性关系,Y=3.453 11×104X-5 107.918 4((R=0.999 9),含量测定的RSD(相对标准偏差)为1.008%.平均回收率100.34%,RSD=0.41%.结论:本方法简单,快速、准确、重现性好,可以用作氟伐他汀钠分散片的含量测定. |
| 关 键 词： | 氟伐他汀钠 HPLC 含量测定 |
Determination of fluvastatin sodium dispersible tablets by HPLC |
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| LIU Yu,ZHANG Nian-jie,LIU Lian-xin,LENG Shi-liang,SUN Ting-ting.Determination of fluvastatin sodium dispersible tablets by HPLC[J].Journal of Jilin Institute of Chemical Technology,2011,28(1):23-25. | |
| Authors: | LIU Yu ZHANG Nian-jie LIU Lian-xin LENG Shi-liang SUN Ting-ting |
| Affiliation: | LIU Yu1,2,ZHANG Nian-jie3,LIU Lian-xin1,LENG Shi-liang1,SUN Ting-ting1(1.Xuzhou College of Industrial Technology,Xuzhou 221140,China,2.China University of Mining and Technology,Xuzhou 221008,3.Yanbian Supervision & Management Bureau for Quality and Techniques,Yanji 133000,China) |
| Abstract: | Objective：To establish HPLC method for determining the content of fluvastatin sodium dispersible tablets.Method：Thermo C18 column was used and the mobile phase was 0.01mol·L-1 disodium hydrogen phosphate and acetonitrile（40∶60）,flow rate was 1.2mL·min-1,wavelength was UV at 305nm and the sample volume was 20μL.Results：The fluvastatin sodium concentration had good liner relationship from 0～100μg·mL-1,Y=3.45311×104X-5107.9184（R=0.9999）.The relative standard deviation of the determination is 1.008%.The average recovery was 100.34%,RSD=0.41%.Conclusion：The method was simple,fast,accurate,and precise,could be use to determine the content of fluvastatin sodium dispersible tablets. |
| Keywords: | fluvastatin sodium HPLC determination of content |
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