CGRP-beta unlike CGRP-alpha has no osteogenic stimulatory effect in vitro |
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Authors: | D Hirt GW Bernard |
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Affiliation: | Department of Neurobiology, School of Medicine and Oral Biology, School of Dentistry UCLA 90095, USA. |
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Abstract: | The purpose of this study is to test whether CGRP-beta has an osteogenic stimulating effect, as does CGRP-alpha, on rat bone marrow cells in vitro. CGRP-beta in different doses was added daily to bone marrow white cells, which were harvested from rats, then seeded onto a previously prepared layer of fibroblasts. CGRP-alpha in different doses was used as a positive control. Fourteen days after the start of the experiment, there was no statistical difference in the number of bone colonies between the control and CGRP-beta dishes. The CGRP-alpha dishes demonstrated an increase in the number of colonies with an increase of peptide dose. |
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