| 治疗急性早幼粒细胞白血病的几个问题 |
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| 引用本文： | 林凤茹,郭晓楠,任金海. 治疗急性早幼粒细胞白血病的几个问题[J]. Canadian Metallurgical Quarterly, 2011, 20(1). DOI: 10.3760/cma.j.issn.1009-9921.2011.01.005 |
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| 作者姓名： | 林凤茹 郭晓楠 任金海 |
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| 作者单位： | 河北医科大学第二医院血液科,石家庄,050000 |
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| 摘 要： | 急性早幼粒细胞白血病(APL)为急性髓系白血病的一个亚型,以进展快,易发生弥散性血管内凝血(DIC)和死亡率高为特征.95%以上APL患者有典型染色体易位t(15;17)形成PMLRARα融合基因.1986年以来,中国首创以全反式维甲酸(ATRA)和亚砷酸(ATO)治疗APL,使APL的转归大大改观,成为仅用药物可治愈的AML.结合作者经验讨论治疗APL中的有关问题.
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| 关 键 词： | 白血病,髓样 治疗 |
Problems in the treatment of acute promyelocytic leukemia |
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| LIN Feng-ru,GUO Xiao-nan,REN Jin-hai. Problems in the treatment of acute promyelocytic leukemia[J]. Canadian Metallurgical Quarterly, 2011, 20(1). DOI: 10.3760/cma.j.issn.1009-9921.2011.01.005 |
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| Authors: | LIN Feng-ru GUO Xiao-nan REN Jin-hai |
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| Abstract: | Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia, is characterized by rapid progress, prone to developing DIC, and high mortality. Typical chromosome translocation with PMLRARα fusion gene occurs in more than 95% of APL cases. Since 1986, the outcome of APL has been significantly improved in our country by firstly using ATRA and ATO for treating APL, making APL of AML curable by chemotherapy only. Based on our limited experiences, we discussed the related problems in the treatment of APL. |
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| Keywords: | Leukemia,myeloid Therapy |
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