| 原发性纵隔大B细胞淋巴瘤研究进展 |
| |
| 引用本文： | 王雅杰,石秀敏.原发性纵隔大B细胞淋巴瘤研究进展[J].Canadian Metallurgical Quarterly,2011,20(5). |
| |
| 作者姓名： | 王雅杰 石秀敏 |
| |
| 作者单位： | 1. 首都医科大学宣武医院病理科
2. 吉林大学第一医院肿瘤中心,长春,130021 |
| |
| 摘 要： | 原发性纵隔大B细胞淋巴瘤(PMBCL)是弥漫大B细胞淋巴瘤(DLBCL)的一种特殊类型,具有独特的临床表现及病理学、分子生物学特征.目前尚无标准的治疗方案,回顾性分析表明第三代的化疗方案优于CHOP方案,利妥昔单抗的应用缓解了这种差异,是否需要接受联合放疗尚无定论.未来将脱氧葡萄糖-正电子发射计算机断层显像(FDG-PET)用于PMBCL的疗效评估,如果能提供可靠的预后信息,就可以减轻治疗强度.
|
| 关 键 词： | 淋巴瘤 B细胞 病理学 临床 治疗 |
Research progress of primary mediastinal large B-cell lymphoma |
| |
| WANG Ya-jie,SHI Xiu-min.Research progress of primary mediastinal large B-cell lymphoma[J].Canadian Metallurgical Quarterly,2011,20(5). |
| |
| Authors: | WANG Ya-jie SHI Xiu-min |
| |
| Abstract: | Primary mediastinal large B-cell lymphoma represents a distinct entity with unique clinicopathologic features and a molecular gene-expression signature. There is no standard regimens. Retrospective analysis suggests that dose-dense and dose-intensive regimens are more effective than CHOP. The addition of rituximab may mitigate such difference. The role of mediastinal radiotherapy upon completion of chemotherapy remains unclear. The role of PET scanning requires prospective examination, which may allow the de-escalation of treatment if it can be shown to yield reliable prognostic information. |
| |
| Keywords: | Lymphoma B-cell Pathology clinical Therapy |
| 本文献已被 万方数据 等数据库收录！ |
|
