| 硼替佐米治疗复发难治性套细胞淋巴瘤的研究进展 |
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| 引用本文： | 丁洋,王晓萌.硼替佐米治疗复发难治性套细胞淋巴瘤的研究进展[J].Canadian Metallurgical Quarterly,2011,20(5). |
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| 作者姓名： | 丁洋 王晓萌 |
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| 作者单位： | 河北医科大学第三医院病理科,石家庄,050051 |
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| 摘 要： | 复发难治性套细胞淋巴瘤(MCL)的治疗是临床医师面临的严峻挑战.近年来,蛋白酶体抑制剂硼替佐米的应用给复发难治性MCL患者的治疗提供了新方法.就硼替佐米治疗复发难治性MCL的机制、临床疗效以及MCL细胞对硼替佐米耐药产生的机制和应对策略进行综述.
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| 关 键 词： | 淋巴瘤 膜细胞 硼替佐米 治疗 |
Research progress of bortezomib therapy in patients with relapsed or refractory mantle cell lymphoma |
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| DING Yang,WANG Xiao-meng.Research progress of bortezomib therapy in patients with relapsed or refractory mantle cell lymphoma[J].Canadian Metallurgical Quarterly,2011,20(5). |
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| Authors: | DING Yang WANG Xiao-meng |
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| Abstract: | Currently refractory and relapsed mantle cell lymphoma (MCL) continues to develope a poor prognosis, and the treatment remains a significant clinical challenge. The use of bortezomib in clinic provides a novel method for the treatment of refractory and relapsed MCL. This review summarizes the mechanism and efficiency of bortezomib in the treatment of MCL and the strategies for overcome of bortezomib resistance. |
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| Keywords: | Lymphoma mantle-cell Bortezomib Therapy |
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