| 11C-胆碱在PET肿瘤显像中的应用 |
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| 引用本文： | 郭喆,张锦明. 11C-胆碱在PET肿瘤显像中的应用[J]. 同位素, 2005, 18(3): 178-182,147 |
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| 作者姓名： | 郭喆 张锦明 |
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| 作者单位： | 中国人民解放军总医院,核医学科,北京,100853 |
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| 摘 要： | ^18F-FDGPET在肿瘤学领域已经得到了深入研究和广泛应用。因大脑皮层对FDG的摄取甚高，并且FDG经泌尿系统进行排泄，使FDGPET显像在颅内及盆腔肿瘤的诊断方面受到限制。新近研究较多的肿瘤显像剂[^11C-甲基]胆碱（^11C-胆碱）在正常脑组织中代谢极低并且不通过泌尿系统排泄，克服了FDG在颅内及盆腔肿瘤临床应用上的不足。^11C-胆碱用于肿瘤显像的原理为：肿瘤细胞复制活跃，细胞膜的生物合成加快，导致肿瘤的胆碱摄取率增高。^11C-胆碱PET显像的初步临床应用表明其在脑瘤、前列腺癌、膀胱癌及妇科肿瘤的良恶性鉴别、疗效监测及复发评价方面比FDGPET显像有更大的优势。在肺癌、食道癌、骨肿瘤及软组织肿瘤的诊断和转移灶探查等方面，若FDG和^11C-胆碱联用可以提高诊断的准确率和灵敏度。^11C-胆碱将是一个很有前途的肿瘤PET显像剂。
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| 关 键 词： | ^11C-胆碱 ^18F-FDG 正电子发射体断层显像 |
| 文章编号： | 1000-7512（2005）03-0178-05 |
| 收稿时间： | 2004-05-26 |
| 修稿时间： | 2004-05-262004-08-24 |
Application of 11C-choline PET in Tumors Imaging |
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| GUO Zhe,ZHANG Jin-ming. Application of 11C-choline PET in Tumors Imaging[J]. Isotopes, 2005, 18(3): 178-182,147 |
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| Authors: | GUO Zhe ZHANG Jin-ming |
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| Affiliation: | Department of Nuclear Medicine, The PLA General Hospital of PLA, Beijing 100853, China |
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| Abstract: | ~(18)F-FDG PET has been widely applied in the diagnosis and therapeutic evaluation in oncology,but it has limitation in diagnosing of some kinds of tumors,such as brain tumor,prostate cancer and bladder cancer because of its metabolism characteristic.[~(11)C-choline] choline(~(11)C-choline) is one of new tumor imaging agents,which has been developed and used for the dection of malignancies.~(11)C-Choline PET is superior to FDG PET in malignancy discrimination,grading,therapeutic monitoring and evalution of brain tumors,prostate tumors,bladder tumors and gynecologic tumors.~(11)C-choline PET is also useful for metastasis dection and diagnosis of other tumors,particularly if it is combined with FDG PET.So,~(11)C-choline is a promising tumor imaging agent. |
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| Keywords: | ^11C-choline ^ 18 F-FDG positron emission tomography |
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