Design of porous polymeric scaffolds by gas foaming of heterogeneous blends |
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| Authors: | A Salerno M Oliviero E Di Maio S Iannace P A Netti |
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| Affiliation: | (1) Department of Materials and Production Engineering & Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy;(2) Italian Institute of Technology (IIT), Via Morego 30, 16163 Genoa, Italy;(3) Institute of Composite and Biomedical Materials, National Research Council of Italy, P.le Tecchio 80, 80125 Naples, Italy; |
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| Abstract: | One of the challenges in tissue engineering scaffold design is the realization of structures with a pre-defined multi-scaled
porous network. Along this line, this study aimed at the design of porous scaffolds with controlled porosity and pore size
distribution from blends of poly(ε-caprolactone) (PCL) and thermoplastic gelatin (TG), a thermoplastic natural material obtained
by de novo thermoplasticization of gelatin. PCL/TG blends with composition in the range from 40/60 to 60/40 (w/w) were prepared
by melt mixing process. The multi-phase microstructures of these blends were analyzed by scanning electron microscopy and
dynamic mechanical analysis. Furthermore, in order to prepare open porous scaffolds for cell culture and tissue replacement,
the TG and PCL were selectively extracted from the blends by the appropriate combination of solvent and extraction parameters.
Finally, with the proposed combination of gas foaming and selective polymer extraction technologies, PCL and TG porous materials
with multi-scaled and highly interconnected porosities were designed as novel scaffolds for new-tissue regeneration. |
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