| (E)-2-[2-甲氧基-5-(2,4,6-三甲氧基苯乙烯磺酰甲基)]苯胺基乙酸钠的简便合成 |
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| 引用本文： | 徐龙飞,马希汉,魏邦国. (E)-2-[2-甲氧基-5-(2,4,6-三甲氧基苯乙烯磺酰甲基)]苯胺基乙酸钠的简便合成[J]. 淮海工学院学报, 2010, 19(3): 40-43 |
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| 作者姓名： | 徐龙飞 马希汉 魏邦国 |
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| 作者单位： | 徐龙飞,马希汉(西北农林科技大学,林学院,陕西,杨凌,712100);魏邦国(复旦大学,化学系,上海,200433) |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 经6步合成了α,β-不饱和砜类化合物2-[2-甲氧基-5-(2,4,6-三甲氧基苯乙烯磺酰甲基)]苯胺基乙酸,总收率为22%。在关键步骤硫醚氧化步骤中,将反应温度由室温改为75℃,收率由55%提高到85%。缩合脱羧反应中,以醋酸铵为碱,此步收率由30%提高到60%,为该类物质的合成提供了适合较大量合成的方法。
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| 关 键 词： | αβ不饱和砜 （E）-2-E2-甲氧基-5-（2 ,4, 6-三甲氧基苯乙烯磺酰甲基）]苯胺基乙酸 合成 |
Convenient Synthesis of Sodium (E)-2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)-acetate |
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| XU Long-fei,MA Xi-han,WEI Bang-guo. Convenient Synthesis of Sodium (E)-2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)-acetate[J]. Journal of Huaihai Institute of Technology:Natural Sciences Edition, 2010, 19(3): 40-43 |
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| Authors: | XU Long-fei MA Xi-han WEI Bang-guo |
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| Affiliation: | 1. College of Forestry, Northwest Agricultural and Forestation University, Yangling 712100, China 2. Dept. of Chemistry, Fudan University, Shanghai 200433, China) |
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| Abstract: | A convenient,reliable and simplified 6-step method for the synthesis of sodium（E）-2-（5-（（2,4,6-trimethoxystyrylsulfonyl）methyl）-2-methoxyphenylamino）-acetate was proposed with the overall yield rate of 22%.In the key step of oxidation,the reaction temperature was changed to 75 ℃ with the increase of yield rate from 55% to 85%.And in condensation,the use of ammonium acetates as the alkali increased the yield rate from 30% to 60%.Such a method could be applied to the mass production of the title product. |
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| Keywords: | α,β-unsaturated sulfone （ E）-2-（ 5- （ （2,4,6-trimethoxystyrylsulfonyl） methyl）-2-me-thoxyphenylamino）-acetate synthesis |
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