基于QuEChERS净化-高效液相色谱-串联质谱法测定水产品中8种抗抑郁类药物残留量

抗抑郁类药物的污染可导致水产品中残留量超标,从而对食品卫生安全构成威胁。采用QuEChERS净化-高效液相色谱-串联质谱法测定,以鱼、虾、蟹、贝等常见水产品作为样品基质,建立西酞普兰、文拉法辛、帕罗西汀、氟西汀、阿米替林、曲米帕明、舍曲林、氯丙咪嗪8种抗抑郁类药物残留量的检测方法。结果表明：8种抗抑郁类药物在0.1～5.0μg/L质量浓度范围内线性良好,相关系数均大于0.999,检出限为0.04～0.06μg/kg,加标回收率为80.0%～110.0%,相对标准偏差为0.23%～5.50%。该方法简单快速、干扰小、线性范围良好,同时具有较好的精密度和准确度。

Simultaneous Determination of Eight Antidepressant Residues in Aquatic Products by QuEChERS Purification Combined with High Performance Liquid Chromatography-Tandem Mass Spectrometry

The pollution of antidepressant drugs can lead to their excess residues in aquatic products, which poses a threat to food hygiene and safety. In this study, quick, easy, cheap, effective, rugged and safe (QuEChERS) purification combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to determine the residues of eight antidepressants, including citalopram, venexaxine, paroxetine, fluoxetine, amitriptiline, tremipramine, sertraline and clomipramine, in common aquatic products such as fish, shrimp, crab and shellfish. The results showed that the linearity of the calibration curves for the eight antidepressants was good in the range of 0.1–5.0 μg/L with correlation coefficients greater than 0.999, the detection limits were 0.04–0.06 μg/kg, and the recoveries of spiked samples were 80.0%–110.0% with relative standard deviation (RSD) of 0.23%–5.50%. This method is simple and rapid and is characterized by low interference, good linearity, and high precision and accuracy.