PLGA/PLA共混纳米纤维膜的结构与性能

 为制备组织工程支架材料，以具有优异生物相容性的PLGA和PLA为原料，通过静电纺丝法制备PLGA/PLA共混纳米纤维膜。通过扫描电镜、流变仪、TG-DSC热分析和电子强力仪测定共混纳米纤维膜的形貌结构、微细结构和力学性能。结果表明：通过静电纺丝法可成功制备PLGA/PLA共混微、纳米级纤维膜。随着PLA共混比例的提高，纺丝液的黏度逐渐提高，使得纳米纤维的直径增大、分布均匀、孔径增大、孔隙率减小；热分析结果表明随着PLA共混比例的增大，支架的结晶度和结构稳定性提高；随着PLA共混比例的增加，支架的断裂强度增加，伸长减小；可通过调节PLGA和PLA的共混比例达到调控支架材料的结构与性能，以满足不同组织工程支架的要求。

Structure and properties of PLGA/PLA blended nanofibrous membrane

To prepare tissue engineering scaffolds,the PLGA/PLA blended nanofibrous membrane was fabricated via electrospinning with biocompatible PLGA and PLA as raw materials.The morphology,microstructure and mechanical properties of the PLGA/PLA blended nanofibers were characterized by means of SEM,rheometer,TG-DSC and tensile tester.The results show that the PLGA/PLA blended micro-and nanofibers can be prepared successfully by electrospinning.The viscosity of the spinning solution increases with the increase of the blended ratio of PLA,making the diameter of the nanofibers increased,distribution more uniform,pore size bigger and porosity decreased.The thermal analysis indicates that the crystallinity and stability of the scaffolds increase,breaking strength improves and elongation decreases with the increase of the blended ratio of PLA.In order to meet the requirments of different tissue engineering scaffolds,the blended ratio can be adjusted to control the structure and properties of the scaffolds.