| 微波辐射合成N~2，9-二乙酰基鸟嘌呤 |
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| 引用本文： | 韩素辉,王东超,张志广,渠桂荣.微波辐射合成N~2，9-二乙酰基鸟嘌呤[J].精细石油化工,2006,23(2):50-52. |
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| 作者姓名： | 韩素辉 王东超 张志广 渠桂荣 |
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| 作者单位： | 河南师范大学化学与环境科学学院,河南,新乡,453007 |
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| 基金项目： | 国家自然科学基金(No．20372018)。 |
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| 摘 要： | 在微波辐射下以对甲苯磺酸(p-TsOH)为催化剂,鸟嘌呤和乙酐为原料合成了药物中间体N~2,9-二乙酰基鸟嘌呤(Ⅲ),产率为91．5%且后处理简便。产物经~1H NMR、~(13)C NMR、IR和元素分析进行了表征。最佳合成条件是：n(乙酐)：n(鸟嘌呤)：n(p-TsOH)=15：1：0．1,微波辐射功率500 W,辐射时间10 min。
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| 关 键 词： | N_2，9-二乙酰基鸟嘌呤 微波 对甲基苯磺酸 |
| 收稿时间： | 2005-09-02 |
| 修稿时间： | 2006-01-18 |
MICROWAVE-ASSISTED SYNTHESIS OF N2, 9-DIACETYLGUANINE |
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| Han Suhui,Wang Dongchao,Zhang Zhiguang,Qu Guirong.MICROWAVE-ASSISTED SYNTHESIS OF N2, 9-DIACETYLGUANINE[J].Speciality Petrochemicals,2006,23(2):50-52. |
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| Authors: | Han Suhui Wang Dongchao Zhang Zhiguang Qu Guirong |
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| Affiliation: | College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, Henan, China |
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| Abstract: | Under microwave irradiation,the important pharmaceutical intermediate,N~2,9-Diacetyl guanine was synthesized from guanine and acetic anhydride using p-toluenesulfonic acid (p-TsOH) as catalyst with the yield of 91.5%.The structure of the product was characteristed by ~1H NMR、~(13)C NMR、IR and elementary analysis.The optimal conditions were obtained as follows:n(acetic an- hydride)/n(guanine)/n(p-TsOH) =15/1/0.1,the microwave power 500 W and reaction time 10 min. |
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| Keywords: | N~2 9-Diacetylguanine microwave p-toluenesulfonic acid |
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