克服FET生物传感器德拜屏蔽效应的研究进展

目前场效应晶体管生物传感器(BioFET)已成功用于生物医学检测。虽然BioFET在生物检测方面具有快速响应、无标记和高灵敏度检测等优点,但是BioFET用于生理环境检测时,容易受到德拜屏蔽效应的影响,导致灵敏度降低甚至无法检测。阐述了BioFET的工作原理;介绍了BioFET目前面临的挑战之一——德拜屏蔽效应;解释了德拜屏蔽效应的原理;探讨了克服德拜屏蔽效应的典型方法:增加德拜长度、优化目标物、优化器件结构以及降低电双层影响,并对这4个方面的研究进展从增强机理、具体方法及检测效果等方面进行了详细的分析和总结。

Research Progress on Overcoming Debye Screening Effect of BioFETs

At present,field effect transistor biosensors(BioFETs)have been successfully used in biomedical detection.BioFETs have the advantages of fast response,label-free and high-sensitivity detection in biological detection,but they are susceptible to the Debye screening effect when they are used for physiological environment detection,resulting in decrease of sensitivity or even undetectability.The principle of BioFETs is described.Debye screening effect,one of the current challenges of BioFETs,is introduced,and the principle of Debye screening effect is explained.The typical methods to overcome Debye screening effect are discussed,including increasing Debye length,optimizing the target,optimizing the structure of the device,and reducing the influence of the electric double-layer.And the research progress in these four aspects is analyzed and summarized in detail from the enhancement mechanism,specific methods and detection effects.