Effects of acute administration of chlorinated water on liver lipids |
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Authors: | Jung-Hwa S Chang Corazon R Vogt Grace Y Sun Albert Y Sun |
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Affiliation: | (1) Environmental Trace Substances Research Center, University of Missouri, 65201 Columbia, MO;(2) Sinclair Comparative Medicine Research Farm and Department of Biochemistry, University of Missouri, 65201 Columbia, MO |
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Abstract: | An acute administration of chlorinated water to rats caused “fatty liver” and indicated a more than 2-fold increase in liver
triacylglycerols at 2 days after administration. The acyl group composition of triacylglycerols and phospholipids in both
liver mitochondria and liver whole homogenate were also altered by the chlorine treatment. Among the phospholipid acyl groups,
there was an increase in the proportion of 20∶4 but a decrease in most other polyunsaturated acyl groups. The acyl group changes
were more obvious with phosphatidylcholines than with phosphatidylethanolamines. Other phospholipids, including cardiolipin
in the mitochondrial membranes, were not greatly altered. Both morphological and biochemical changes were maximum at 2 days
after the treatment and were fully recovered after 10 days. The disturbance of a number of enzymatic processes in the liver
membranes may account for a large part of the changes observed. |
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