洋葱伯克霍尔德复合体研究新进展

洋葱伯克霍尔德复合体(Burkholderia cepacia complex, Bcc)是一组革兰阴性非发酵菌,是一种重要的条件致病菌,在肺囊性纤维化(CF)和慢性肉芽肿(CG)患者中特别容易引起感染,使患者出现无症状带菌、慢性感染或洋葱综合症。随着抗生素的大量使用,洋葱伯克霍尔德复合体引起上述两种疾病以外感染的报道逐渐增多,可引起肺炎、败血症、伤口感染、深部脓肿、尿路感染等。本文就洋葱伯克霍尔德复合体的基因型,流行病学特征、鉴定方法、毒力因子、耐药机制等方面的研究新进展进行了综述。

Advances in the study of Burkholderia cepacia complex

The Burkholderia cepacia complex(Bcc) is a group of nonfermenter aerobic gram-negative bactetia also an important opportunistic pathogens which easily causes infections in cystic fibrosis patients and chronic granulomatous disease. All of this result in patients asymptomatic carriage, chronic infection or cepacia syndrome. Besides CF and CG, cases infected of Burkholderia cepacia complex are growing because antimicrobial agents abuse, it induces pneumonia, blood poisoning, wound infected, deeping abscess and urinary tract infections. The advances in the study of the Burkholderia cepacia complex in genomovars, epidemiology characteristic identification approach,virulent factor and resistant mechanism are reviewed in this paper.