Conformational probes for elucidating the nature of substance P binding to the NK1 receptor: initial efforts to map the Phe7-Phe8 region |
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Authors: | Y Tong YM Fobian M Wu ND Boyd KD Moeller |
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Affiliation: | Department of Chemistry, Washington University, St. Louis, MO 63130, USA. |
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Abstract: | Three substance P analogs with conformation constraints in the Phe7-Phe8 region have been prepared in connection with an effort to differentiate two families of potential conformations for the binding of substance P to its NK1 receptor. While the analogs did not bind the NK1 receptor with high affinity, the synthesis of the analogs demonstrated the utility of a general method for constructing piperazinone based peptidomimetics. |
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