| 3,4-二甲氧基苯乙胺的合成 |
| |
| 引用本文： | 黄红霞,林原斌.3,4-二甲氧基苯乙胺的合成[J].化工中间体,2007(5):10-11,30. |
| |
| 作者姓名： | 黄红霞 林原斌 |
| |
| 作者单位： | 1. 桂林工学院材料与化学工程系,广西,桂林,541004
2. 湘潭大学,化学学院,湖南,湘潭,411105 |
| |
| 摘 要： | 对芳香乙胺化合物进行了研究,以选取适合工业生产的合成方法.邻苯二酚经醚化得到1,2-二甲氧基苯,收率96.7%,再选用高选择性的溴化剂溴化,收率96.5%,经格氏反应和羟乙基化反应制备3,4-二甲氧基苯乙醇,醇与对甲苯磺酰氯反应得到酯,收率97.0%,最后经Gabriel法可以制备3,4-二甲氧基苯乙胺,此步反应收率68.5%.通过实验对各步反应条件进行优化,为相关产品的研究开发提供了有效的途径.
|
| 关 键 词： | 3 4-二甲氧基苯乙胺 格氏反应 Gabriel反应 |
| 文章编号： | 1006-253x（2007）05-010-2 |
| 修稿时间： | 2007-03-12 |
The Synthesis of 3,4-dimethoxy Phenethylamine |
| |
| Authors: | HUANG Hong-xia LIN Yuan-bin |
| |
| Affiliation: | 1.The Department of Material and Chemistry of Guilin University of Technology, Guilin 541004,Guangxi, China; 2.College of Chemistry, Xiangtan university, Xiangtan 411105,Hunan,China |
| |
| Abstract: | A new route to produce 3,4-dimethoxy phenethylamine was provided.1,2-Dihydroxy benzene was reacted with dimethyl sulfate to get 1,2-dimethoxy benzene,the yield was 96.7%.After the ether was brominated with high-selective bromating agent,the product could be obtained through Grignard reaction,esterification(the yield was 97.0%) and Gabriel reaction(the yield was 68.5%).The conditions were optimized and it provided an effective approach to produce correlative products. |
| |
| Keywords: | 3 4-dimethoxy phenethylamine Grignard reaction Gabriel reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
