| N-氯乙酰基-N-异丙基-4-氯苯胺的合成研究 |
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| 引用本文： | 陈同明,张迎芬,宋静德,刘德全. N-氯乙酰基-N-异丙基-4-氯苯胺的合成研究[J]. 化工中间体, 2007, 0(5): 3-5 |
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| 作者姓名： | 陈同明 张迎芬 宋静德 刘德全 |
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| 作者单位： | 江苏安邦电化有限公司,江苏,淮安,3556026 |
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| 摘 要： | 研究了N-氯乙酰基-N-异丙基-4-氯苯胺的制备工艺.以对硝基氯苯、丙酮为原料,复合钯/碳催化剂,1.0MPa压力下一步制得N-异丙基-4-氯苯胺,采用正交法确定了烷基化反应的优化的工艺条件.在优化的条件下,对氯硝基苯转化率99%,N-异丙基-4-氯苯胺选择性可达98%.对硝基氯苯经N-烷基化,N-酰氯化二步总收率92%,产品N-氯乙酰基-N-异丙基-4-氯苯胺纯度大于98%
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| 关 键 词： | N-氯乙酰基-N-异丙基-4-氯苯胺 N-异丙基-4-氯苯胺 烷基化 |
| 文章编号： | 1004-253x（2007）05-003-3 |
| 修稿时间： | 2007-03-12 |
Study on the Synthesis of N-chloroacetyl-N-isopropyl-4-Cloroaniline |
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| CHEN Ton-ming,ZHANG Ying-fen,SONG Jing-de,LIU De-quan. Study on the Synthesis of N-chloroacetyl-N-isopropyl-4-Cloroaniline[J]. , 2007, 0(5): 3-5 |
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| Authors: | CHEN Ton-ming ZHANG Ying-fen SONG Jing-de LIU De-quan |
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| Affiliation: | Jiangsu Anpon Electrochemical Co.,Ltd.Huaian 223002,Jiangsu,China |
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| Abstract: | An improved method of preparing 4-cloro-N-isopropyl-N-chloro-acetylaniline from N-isopropyl-4-chloroaniline was introduced which was prepared in one step with 4-chlorobenzene and acetone as raw material and mixture of Pd/C as catalyst at pressure of 1.0MPa.The optimum reaction conditions were determined by orthogonal experiments.Then N-chloroacetyl-N-isopropyl-4-Cloro-aniline was synthesized through two steps of reaction i.e.N-alkylation,N-acylchloridation,the yied was 92%,the purity was higher than 98% under optimum reaction conditions. |
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| Keywords: | N-chloroacetyl-N-isopropyl-4-cloroaniline N-isopropyl-4-cloro-aniline N-alkylation |
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