| 4-氯-1-甲基-3-硝基-2(1H)-喹啉酮的合成 |
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| 引用本文： | 陈浩,李杰,陈国良,周勋,陆秀宏.4-氯-1-甲基-3-硝基-2(1H)-喹啉酮的合成[J].化学试剂,2010,32(1). |
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| 作者姓名： | 陈浩 李杰 陈国良 周勋 陆秀宏 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 以N-甲基苯胺为起始原料,经过环合反应制得4-羟基-1-甲基-2(1H)-喹啉酮,再经硝化和氯代反应合成了目标化合物,该方法所用原料廉价易得,产物处理简单,适合工业化生产,总收率可达51.9%。
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| 关 键 词： | 4-氯-1-甲基-3-硝基-2(1H)-喹啉酮 合成 N-甲基苯胺 4-羟基-1-甲基-2(1H)-喹啉酮 |
Study on synthesis of 4-chloro-1-methyl-3-nitro-2(1H)-quinolone |
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| CHEN Hao,LI Jie,CHEN Guo-liang,ZHOU Xun,LU Xiu-hong.Study on synthesis of 4-chloro-1-methyl-3-nitro-2(1H)-quinolone[J].Chemical Reagents,2010,32(1). |
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| Authors: | CHEN Hao LI Jie CHEN Guo-liang ZHOU Xun LU Xiu-hong |
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| Abstract: | A new convenient method for synthesis of 4-chloro-1-methyl-3-nitro-2(1H)-quinolone using N-methylaniline as the starting material,via cyclization,nitration and chlorination under mild conditions was carried out,with a total product yield of 51.9%.Compared to the literature method,the new method was low in cost,featuring an easy purification procedure with broad prospects for commercial scale-up. |
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| Keywords: | 4-chloro-1-methyl-3-nitro-2(1H)-quinolone synthesis N-methylaniline 4-hydroxy-1-methyl-2(1H)-quinolone |
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