| 不同保护剂浓度和不同降温速率对脂质体玻璃化转变温度的影响 |
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| 引用本文： | 刘占杰,华泽钊,陶乐仁,刘宝林. 不同保护剂浓度和不同降温速率对脂质体玻璃化转变温度的影响[J]. 低温工程, 2000, 0(6): 1-5 |
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| 作者姓名： | 刘占杰 华泽钊 陶乐仁 刘宝林 |
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| 作者单位： | 上海理工大学制冷与低温技术研究所上海 200093 |
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| 基金项目： | 国家自然科学基金重点项目(59836240)和上海市博士点建设基金资助。 |
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| 摘 要： | 玻璃化转变是动力学的非平衡过程，玻璃化转变量温度是和过程有关的参数。测量了在降温速率分别为５℃/min和１０℃/miｎ，升温速率为１０℃／ｍｉｎ条件下，葡萄糖、蔗糖、甘露醇、海藻糖浓度为５％（Ｗ／Ｖ）的脂质体悬浮的玻璃化转变温度Ｔ‘g，在降温速率为５℃ｍｉｎ、升温为１０℃/min条件下，测量了葡萄糖、蔗糖、甘露醇、海藻糖浓度为１５％（Ｗ／Ｖ）的脂质体的Ｔ’ｇ；并分析了不同降温速率和不同保护剂浓度对脂质体玻璃化转变温度Ｔ’g的影响因素。
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| 关 键 词： | 玻璃化转变温度 脂质体 保护剂 低温冷冻干燥 |
| 修稿时间： | 2000-06-12 |
THE EFFECT OF CRYOPROTECTANT CONCENTRATION AND COOLING RATE ON THE GLASS TRANSITION TEMPERATURE OF LIPOSOME |
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| Liu Zhanjie,HUA Zezhao,Tao Leren,Liu Baolin. THE EFFECT OF CRYOPROTECTANT CONCENTRATION AND COOLING RATE ON THE GLASS TRANSITION TEMPERATURE OF LIPOSOME[J]. Cryogenics, 2000, 0(6): 1-5 |
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| Authors: | Liu Zhanjie HUA Zezhao Tao Leren Liu Baolin |
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| Abstract: | Glass transition is a dynamic imbalance process.The glass transition temperatures～Tg′ of liposome suspensions are measured by DSC in which the concentration of glucose,sucrose,mannitol,trehalose are 5%(W/V),the cooling rate is 5 °C/min and 10 °C/min,the heating rate is 10 °C/min.The glass transition temperatures Tg′ of liposome are measured in which the concentration of glucose,sucrose,mannitol,trehalose are 15%(W/V),the cooling rate is 5 °C/min,the heating rate is 10 °C/min.The glass transition temperatures Tg′ of liposome suspensions in which the concentration of cryoprotectant is 15% is 2 K larger than which the concentration of cryoprotectant is 5%.The glass transition temperatures Tg′ will rise 1 K when the cooling rate rises from 5 °C/min to 10 °C/min.The effect of cryoprotectant concentration and cooling rate on the glass transition temperature is analyzed. |
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| Keywords: | glass transition temperature liposome cryoprotecta |
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