Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity |
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| Authors: | Chu-Hung Lin Hsun-Shuo Chang Hsiang-Ruei Liao Ih-Sheng Chen Ian-Lih Tsai |
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| Affiliation: | 1.School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: (C.-H.L.);2.Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: (H.-S.C.);3.Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan; E-Mail: |
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| Abstract: | Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3–10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1–10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM. |
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| Keywords: | Rhaphiolepis indica var tashiroi Rosaceae roots triterpenoids anti-inflammatory activity inhibition of superoxide production |
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