Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection |
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| Authors: | Yanning Ma Xian Wang Hongchuan Jin |
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| Affiliation: | Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China; E-Mails: (Y.M.); (X.W.) |
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| Abstract: | Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection. |
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| Keywords: | cancer biomarker DNA methylation miRNAs |
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