Molecular Motors and Apical CFTR Traffic in Epithelia |
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Authors: | Dmitri V Kravtsov Nadia A Ameen |
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Affiliation: | 1.Department of Pediatrics/Gastroenterology & Hepatology, School of Medicine, Yale University, New Haven, CT 06520, USA; E-Mail: ;2.Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06520, USA |
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Abstract: | Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases. |
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Keywords: | CFTR trafficking myosins microtubules actin transport |
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