Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers |
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| Authors: | Li Xu Guo-Liang Liao Xiang Chen Cun-Yuan Zhao Hui Chao Liang-Nian Ji |
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| Affiliation: | MOE Laboratory of Bioinorganic and Synthetic Chemistry, MOE Laboratory of Gene Engineering, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China |
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| Abstract: | Two new trinuclear ruthenium(II) complexes [(bpy)6Ru3(tpbip)]6+ (1) and [(bpy)6Ru3(tptaip)]6+ (2) (bpy = 2,2′-bipyridine, tpbip = 1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip = 2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the G-quadruplex. |
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