Improving the relaxivity by dimerizing Gd-AAZTA: Insights for enhancing the sensitivity of MRI contrast agents |
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| Authors: | Eliana Gianolio Kondareddiar Ramalingam Bo Song Ferenc Kalman Silvio Aime Rolf Swenson |
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| Affiliation: | 1. Dipartimento di Chimica IFM and Centro di Imaging Molecolare, Università di Torino, Via Nizza 52, 10125 Torino, Italy;2. Bracco Research USA Inc, Ernst Felder Labs, 305 College Road East, Princeton, NJ 08540, USA |
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| Abstract: | The synthesis of a dimeric derivative of Gd-AAZTA is reported. It retains the basic properties of the parent complex (q = 2, high stability) and displays a relaxivity of 14.0 mM?1 s?1 at 20 MHz and 298 K. The outstanding relaxivity is the result of the increased molecular reorientational time and of the contribution arising from 4 to 5 water molecules in the second coordination sphere of the Gd(III) ions. |
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