A New Disintegrant for Pharmaceutical Dosage Forms

The current research paper introduces a biodegradable, nontoxic polymer as a new disintegrant for pharmaceutical dosage forms. Gellan gum is a linear anionic polysaccharide approved by the U.S. Food and Drug Administration (FDA) for industrial use as a food additive. Experiments were carried out to evaluate the disintegrant property of gellan gum by taking ibuprofen as a model drug. The study included determination of optimum disintegrant concentration, effect of various binders, and suitable mode of incorporation of the disintegrant. The newly investigated disintegrant was compared with the conventional disintegrants to determine its relative efficiency.