No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood |
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Authors: | A Léonard ED Léonard GB Gerber MC Crutzen-Fayt F Richard JG Gueulette NB Akhmatullina |
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Affiliation: | Teratogenicity and Mutagenicity Laboratory, Catholic University of Louvain, Avenue E. Mounier 72, UCL 7237, Brussels 1200, Belgium. leonard@farm.ucl.ac.be |
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Abstract: | Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood. |
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