Synthesis and characterization of biodegradable non-toxic poly(ester-urethane-urea)s based on poly(ε-caprolactone) and amino acid derivatives |
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Authors: | A. Marcos-Ferná ndez,G.A. Abraham,J. San Romá n |
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Affiliation: | a Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Cientificas (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain b Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA), (UNMdP-CONICET), J.B. Justo 4302, B7608FDQ Mar del Plata, Argentina |
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Abstract: | Non-toxic biodegradable linear poly(ester-urethane-urea)s with different hydrophilic character were synthesized from poly(ε-caprolactone) as macrodiol, l-lysine diisocyanate (LDI) and ethyl ester l-lysine or l-ornithine as chain extenders. Linear segmented polymers were synthesized by the prepolymer method with a tertiary amine playing a critical role in the chain extension in heterogeneous conditions. The prepared segmented polymers were fully chemically and physically characterized, including water uptake and hydrolytic stability measurements. Depending on the poly(ε-caprolactone) length, the segmented polymers were amorphous or semicrystalline. The crystallinity degree strongly affected the mechanical properties and water uptake behaviour. |
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Keywords: | Biodegradable polyurethanes Lysine diisocyanate Amino acid chain extenders |
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