A Comparison of Dissolution from Commercial Tablets and from Capsules Containing a Powdered Tablet

In clinical trials it may be necessary to convert a commercial tablet to a capsule so that the identity of each drug being tested remains unknown until the trial is completed. This study shows that for six commercial tablets, after pulverization and encapsulation of the powder, the in vitro dissolution was faster for one product, slower for two products and essentially unchanged for three products.