| 噻唑-4-甲酸的合成 |
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| 引用本文： | 邱滔,吴增辉,吕新宇. 噻唑-4-甲酸的合成[J]. 江苏石油化工学院学报, 2012, 0(1): 21-23 |
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| 作者姓名： | 邱滔 吴增辉 吕新宇 |
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| 作者单位： | 常州大学设计研究院,江苏常州213164 |
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| 摘 要： | 以L-半胱氨酸盐酸盐与甲醛为起始原料,经缩合酯化得到噻唑烷-4-甲酸甲酯,再在二氧化锰作用下氧化合成噻唑-4-甲酸甲酯,水解得到噻唑-4-甲酸。氧化反应最佳反应条件为n（噻唑-4-甲酸甲酯）∶n（MnO2）=1∶23、MnO2活化温度为300℃、80℃反应48h。氧化反应收率为80.8%。
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| 关 键 词： | 噻唑-4-甲酸 氧化反应 合成 |
Synthesis of Thiazole-4-Carboxylic Acid |
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| QIU Tao,WU Zeng-hui,LV Xin-yu. Synthesis of Thiazole-4-Carboxylic Acid[J]. Journal of Jiangsu Institute of Petrochemical Technology, 2012, 0(1): 21-23 |
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| Authors: | QIU Tao WU Zeng-hui LV Xin-yu |
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| Affiliation: | (Institute of Design and Research,Changzhou University,Changzhou 213164,China) |
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| Abstract: | Methyl thiazolidine-4-carboxylate was synthesized from L-Cysteine hydrochloride and formaldehyde by condensation and esterification.Methyl thiazole-4-carboxylate was synthesized by oxidation reaction.Thiazole-4-carboxylic acid was achieved from hydrolysis reaction.The mole ratio of methyl thiazole-4-carboxylate to MnO2 was 1∶23,the activation temperature of MnO2 was 300 ℃,reaction for 48 h at 80 ℃.The yield of oxidation reaction was 80.8%. |
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| Keywords: | Thiazole-4-carboxylic acid oxidation reaction synthetize |
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