Framework for the quantitative modelling of the European methodology for qualification of non-destructive testing |
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| Affiliation: | 1. Laboratoire de Synthèse Organique et Molécules Bioactives, Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg, France;2. Institut Universitaire de France, 103 Bd Saint-Michel, 75005 Paris, France;3. ICSN-CNRS (Bat. 27)—LabEx LERMIT, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France;4. ICOA, UMR 7311, Université d’Orléans et CNRS, rue de Chartres, BP 6759, 45067 Orléans, France;1. Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, 80539 Munich, Germany;2. Department of Chemistry, University of Debrecen, PO Box 20, 4010 Debrecen, Hungary;1. Discovery Research, Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India;2. 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark;3. NNF, Center for Protein Research and NNF Center for Basic Metabolic Research, University of Copenhagen, Denmark;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba 288-0025, Japan;2. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan;3. Department of Pharmacology, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan;4. Department of Biochemistry, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;5. Department of Pharmacology, Faculty of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan;6. Department of Clinical Medicine, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba 288-0025, Japan |
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| Abstract: | The European methodology for qualification of non-destructive testing has been adopted as the basis of inspection qualifications for nuclear utilities in many European countries. According to this methodology, the inspection qualification is based on a combination of technical justification and practical trials. The methodology is qualitative in nature, and it does not give explicit guidance on how the evidence from the technical justification and results from trials should be weighted. This article discusses the quantification of the methodology. A structured and quantified approach to combine evidence from technical justifications and practical trials would provide improved transparency in the qualification process. A Bayesian framework for the quantification process is presented and examples of possibilities to combine technical justification and trial results are given. The article also identifies the areas needing further development. |
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