N-nitrosodimethylamine analysis in Estonian beer using positive-ion chemical ionization with gas chromatography mass spectrometry |
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| Affiliation: | 1. CEA, Laboratoire de Physiologie Cellulaire Végétale, 38054 Grenoble, France;2. CNRS, UMR5168, 38054 Grenoble, France;3. Université de Grenoble, 38000 Grenoble, France;4. INRA, 38054 Grenoble, France;5. UMR QualiSud, UFR des Sciences Pharmaceutiques et Biologiques, Université de Montpellier 1, 34093 Montpellier, France;6. CEA-DEN, Laboratoire des Procédés Supercritiques et de Décontamination, 30207 Bagnols sur Cèze, France;7. Institut Laue Langevin, Division Science, 38042 Grenoble, France;1. College of Civil Engineering and Architecture, Zhejiang University of Technology, Hangzhou 310014, China;2. State Key Laboratory of Urban Water Resource and Environment, School of Municipal & Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China;3. College of Environment, Zhejiang University of Technology, Hangzhou 310014, China;1. School of Metallurgy and Resource, Anhui University of Technology, Maanshan 243002, China;2. Department of Chemical Engineering, Chung Yuan Christian University, ChungLi 320, Taiwan, China;3. Research and Development Center for Environmental Technology, Chung Yuan Christian University, ChungLi 320, Taiwan, China;1. Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, PR China;2. Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, PR China;3. Pharmaceutical Teaching Laboratory, Chongqing Medical University, Chongqing, PR China;4. College of Laboratory Medicine, Chongqing Medical University, Chongqing, PR China;1. IRIS - International Research Institute of Stavanger, P.O. Box 8046, N-4068, Stavanger, Norway;2. University of Stavanger, Faculty of Science and Technology, Department of Mathematics and Natural Science, N-4036 Stavanger, Norway;3. Shell Global Solutions International BV, PO Box 60, 2280 AB, Rijswijk, The Netherlands;1. Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan 250100, PR China;2. Key Laboratory for Special Functional Aggregated Materials of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China |
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| Abstract: | N-nitrosodimethylamine (NDMA) is a potent animal carcinogen that has been detected in trace levels in beers. A total of 264 beer samples were analyzed for their NDMA content. For cleaning of the sample the two-step solid-phase extraction with Extrelut and Florisil sorbents were used. NDMA was separated by gas chromatography and detected by positive-ion chemical ionization using ammonia as reagent gas. The HP 6890 Plus GC/HP 5973 MSD with positive-ion chemical ionization option was used in the selected ion-monitoring mode. The limit of detection for NDMA using this method was 0.15 ppb with about 70–80% recovery. Of 158 Estonian beers analyzed during 2003–2004, the average NDMA level was found to be 0.20 ppb. Of 106 imported beer samples the average NDMA level was found to be 0.21 ppb. |
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