The absorption of fish oils and concentrates |
| |
Authors: | R G Ackman |
| |
Affiliation: | (1) Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Box 1000, B3J 2X4 Halifax, Nova Scotia, Canada |
| |
Abstract: | Both preventive and curative therapies have created a considerable demand for eicosapentaenoic (EPA) and docosahexaenoic (DHA)
acids. The most common sources for ω3 fatty acids are fish oil. The concentrations of EPA and DHA in commercial oils, after
modest enrichment, reach about 300 mg/g; alternative technologies can produce reasonably priced fish oils containing 400 or
even 500 mg/g of ω3 acids. When the acids are liberated from the glycerides, concentrates of ethyl esters or free acids with
65 to 70% total ω3 fatty acids (at least 50% EPA+DHA) are readily prepared. Difficulties have arisen because most clinical
trials have used fish oils of unspecified composition, and some trials are now based on either ethyl esters or free acids.
There are at least three different, but not mutually exclusive, absorption routes in humans, namely the preduodenal route,
the lymphatic routevia chylomicrons, and the routevia the portal vein to the liver. This makes it difficult to compare results. The difficulty in obtaining dose-related clinical
data may in part be due to the form in which the ω3 acids are offered and due in part to the natural presence of these fatty
acids in the body. The nontriglyceride forms, especially the free acids, have been advocated for standardization of trials
to facilitate interlaboratory comparisons.
Based on a paper presented at the Symposium on Milk Lipids held at the AOCS Annual Meeting, Baltimore, MD, April 1990. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|