Tailoring the pore structure of PCL scaffolds for tissue engineering prepared via gas foaming of multi-phase blends |
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| Authors: | A Salerno E Di Maio S Iannace P A Netti |
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| Affiliation: | (1) Interdisciplinary Research Centre on Biomaterials (CRIB), P.le Tecchio 80, 80125 Naples, Italy;(2) Italian Institute of Technology (IIT), P.le Tecchio 80, 80125 Naples, Italy;(3) Institute of Composite and Biomedical Materials, National Research Council (IMCB-CNR), P.le Tecchio 80, 80125 Naples, Italy;(4) Department of Materials and Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy |
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| Abstract: | The aim of this study was the design of poly(ε-caprolactone) (PCL) scaffolds characterized by well controlled pore structures
obtained by gas foaming of multi-phase blends of PCL and thermoplastic gelatin (TG). Co-continuous blends made of PCL and
TG were prepared by melt mixing and, subsequently gas foamed in an autoclave to induce the formation of the porous network.
A mixture of N2 and CO2 was used as blowing agent and the foaming process performed at temperature higher than PCL melting, in the range 70–110 °C.
The foams were finally soaked in water at 37 °C to selectively extract the TG and achieve the final pore structure. The results
of this study demonstrated that the proposed approach allowed to tailor the micro-structural properties of PCL scaffolds for
tissue engineering. |
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