Effect of iron, zinc, and copper on lipid peroxidation in liver in vivo

Changes in the levels of lipid peroxides, natural antioxidants (NA), iron, zinc and copper as well as the ability of the lipid substrate to oxidize in animal liver in the presence of iron, zinc and copper have been studied. It has been found that those metals increase the amplitude of natural fluctuations in iron, zinc and copper levels in the liver (by 5-30% in comparison with control). Within the first few hours following administration of iron and copper, the concentration of lipid peroxidation (LPO) products in animal livers increases, while the NA level and lipid oxidizeability decrease, in contrast. Zinc inhibits LPO in the liver within the first few hours following the injection. The changes in the content of NA, lipid oxidizeability and the level of LPO products in animal livers following iron, zinc and copper administration are phase-dependent. Data from regression analysis indicate a direct dependence (kcor = 0.98 at p < or = 0.05) between lipid oxidizeability and NA content in the liver following administration of iron, zinc and copper which, in turn, is suggestive of the lack of disturbances in the system of NA regulation