Study of the preparation,properties and kinetics of anion release in drug intercalated magnetic nanohybrids |
| |
| Authors: | HS Panda D Bahadur |
| |
| Affiliation: | 1. Department of Materials Engineering, Defence Institute of Advance Technology, Pune 411025, India;2. Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai 400076, India;1. Department of Chemical Engineering, St. Joseph’s College of Engineering, Chennai, 600119, India;2. Department of Chemical Engineering, SSN College of Engineering, Chennai, 603110, India;1. State Key Laboratory for Infectious Diseases Diagnosis and Therapy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;2. Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, China;3. Zhejiang Academy of Medical Sciences, Hangzhou, China;4. Hangzhou Normal University School of Public Health, Hangzhou, China;5. Department of Basic Science, Division of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA;6. Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;1. National Authority for Remote Sensing and Space Sciences, 23 Joseph Broz Tito Street, El-Nozha El-Gedida, Cairo, Egypt;2. Institut für Angewandte Geowissenschaften, Strukturgeologie and Tektonophysik, Karlsruhe Institute of Technology, Hertzstrasse 16, 76187 Karlsruhe, Germany;3. Independent researcher, Rathausstr. 15, 69181 Leimen, Germany;1. Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland;2. Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89B, 61-614 Poznań, Poland;1. Department of Benign Hematology, University of Texas MD Anderson Cancer Center, Houston, TX;2. Gene Therapy Research Unit, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea;3. Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX;4. Department of Stem Cell Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX;5. Department of Physiology, Temple University Medical School, Philadelphia, PA;6. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX;7. Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, TX |
| |
| Abstract: | We report a new magnetic nanohybrid material to make layered double hydroxides (LDHs) as a targeted drug carrier. The magnetite prepared using a modified conventional coprecipitation technique was embedded in to the fluvastatin intercalated hydrophobic anionic clay through one step process. XRD analysis shows a decrease in lattice parameter of magnetite which is due to generation of stress by the LDHs. Filtered HRTEM image indicates that the magnetic nanohybrid consists of well-defined composite structure and the diameter is around 13 nm. Further, it is shown through magnetisation and ESR study that the exchange interaction between magnetite and drug intercalated LDHs layers shifted the TB of Fe3O4 in magnetic nanohybrid to lower temperatures. In vitro release study of nanohybrid particles at pH 7.4 in PBS and at 37 °C show a faster release for magnetic nanohybrids. The mechanism is probably due to combined effect of interparticle and heterogeneous diffusion via anionic exchange. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
