Δ9 desaturase activity in normal mouse liver and hepatoma SS1K |
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| Authors: | Osvaldo Mercuri Maria Elena De Tomas |
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| Affiliation: | (1) Cátedra de Bioquímica, Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina;(2) Present address: Carrera del Investigador, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina |
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| Abstract: | The activity of Δ9 desaturase was determined in the microsomal fraction of normal mouse liver and hepatoma SS1K in the presence
of the 105,000 × g supernatant. Neither hepatic nor hepatoma soluble fractions were able to modify the low desaturating capacity.
Two enzymes from the microsomal electron transport chain associated with Δ9 desaturase, namely NADH-cytochrom b5 reductase and NADH-cytochrome C reductase were also measured. The results indicate that the low Δ9 desaturase activity in
hepatoma SS1K could be related to the reduced amount of desaturase. |
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