Cytogenetic damage and mutagenesis in mammalian and human cells induced by ionizing radiation with varying LET

Base oneself on analysis of literature and proper data the conclusion was inferred about essential role of structural chromosomal (and gene) damages for radiation-induced mutagenesis of mammalian and human cells (for example HPRT loci). The evidences are adduced of their increase role in mutagenesis after influence of ionizing radiations with high LET. The consequences of HPRT-gene damages have been examined hypothetically.