Synthesis and characterization of NaYF_4:Yb~(3+),Er~(3+)@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells |
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| Affiliation: | 1. Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;2. Graduate University of Science and Technology - Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Department of Chemistry, Hanoi Medical University, 1-Ton That Tung, Dong Da, Hanoi, Viet Nam;4. Department of Chemistry, Hanoi University of Mining and Geology, 18-Pho Vien, Bac Tu Liem, Hanoi, Viet Nam;5. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;6. Duy Tan University, K7/25 Quang Trung, Da Nang, Viet Nam;1. Institute of Chemistry, University of Silesia, 9 Szkolna Street, Katowice 40-007, Poland;2. Institute of Materials Science, University of Silesia, 75 Pułku Piechoty 1A Street, Chorzów 41-500, Poland;1. Institute of Low Temperature and Structure Research, Polish Academy of Science, Okólna 2, Wrocław, 50-422, Poland;2. XTPL S.A., Stabłowicka 147, Wrocław, 54-066, Poland;1. National University of Science and Technology MISiS, 119049 Moscow, Leninsky Av., 4, Russia;2. South Ural State University, 454080 Chelyabinsk, Lenin Av., 76, Russia;3. Scientific-Practical Materials Research Centre of NASB, 220072 Minsk, Belarus;4. CFisUC, Department of Physics, University of Coimbra, 3004-516 Coimbra, Portugal;5. National Research University of Electronic Technology “MIET”, 124498 Zelenograd, Moscow, Russia;6. Institute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., 119991 Moscow, Russia;7. Institute of Physics, Polish Academy of Sciences, 02-668 Warsaw, Poland;8. The University of Texas at El Paso, El Paso, TX 79968-0515, USA;1. Key Laboratory of Advanced Functional Materials of Nanjing, College of Environmental Science, Nanjing Xiaozhuang University, Nanjing, 211171, China;2. College of Science, Nanjing Forestry University, Nanjing, 210037, PR China;1. Institute of Chemistry, University of São Paulo, Butantã 748, 26077 São Paulo, Brazil;2. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wroclaw, Poland;3. Brazilian Nanotechnology National Laboratory (LNNano–CNPEM), Campinas 13083-100, São Paulo, Brazil;4. Department of Chemistry, Federal University of Espirito Santo, Vitoria 29220-000, Brazil |
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| Abstract: | Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer cells.These nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to infrared.In this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF_4:Yb~(3+),Er~(3+)for biomedical application.After synthesis,these NaYF_4:Yb~(3+),Er~(3+)nanophosphors were functionalized with aminosilanes and folic acid.Folic acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via endocytosis.The sizes of the functionalized NaYF_4:Yb~(3+),Er~(3+)@silica-N=FA(folic acid) nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 nm.Phase structure of NaYF_4:Yb~(3+),Er~(3+)is in hexagonal crystal system.The photo luminescence(PL) spectra of the functionalized NaYF_4:Yb~(3+),Er~(3+)@silica-N=FA nanophosphors were measured.These nanophosphors emit in red color with the strongest band at 650 nm under 980 nm excitation.This result can provide NaYF_4:Er~(3+),Yb~(3+)@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine. |
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| Keywords: | Upconversion luminescence Nanophosphors Bioimaging Cancer cell Rare earths |
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