Reconstruction of the visceral cranium by the replantation of a resected bone segment subjected to extracorporeal freezing in benign tumors and dysplastic processes

The new method for surgical treatment of benign tumors and dysplastic processes in the facial skull bones includes resection of the involved segment of the bone, its mechanical treatment, extracorporeal freezing, sterilization, and replantation. Biophysical studies revealed that 10-min freezing of the preparation in liquid nitrogen followed by slow defrosting kills tumor cells. Animal experiments demonstrated excellent osteoplastic properties of thus treated replants. Based on the results of treatment of 29 patients, the authors defined the indications for such treatment and demonstrated its high efficacy in benign tumors and dysplastic processes in the facial skull.