| 布洛芬乙酯的分子筛催化合成 |
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| 引用本文： | 刘勇,罗氚芸.布洛芬乙酯的分子筛催化合成[J].化学世界,2000,41(2):90-92. |
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| 作者姓名： | 刘勇 罗氚芸 |
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| 作者单位： | [1]云南大学省工业微生物发酵工程特点实验室 [2]云南师大省农村能源工程特点实验室 |
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| 基金项目： | 云南省科委应用基础研究基金!（94B006Q） |
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| 摘 要： | 消旋布洛芬乙酯作为微生物拆分消旋药物布洛芬获取ｓ（＋ ）－布洛芬的前体。今采用ＨＺＳＭ－５ 分子筛作为催化剂，消旋布洛芬与乙醇摩尔比为１∶１．２，苯为溶剂及带水剂，成功地合成了消旋布洛芬乙酯。结果表明，反应条件温和，产物容易提纯，产率达９２％ 。产物结构经ＩＲ、ＧＣ－ＭＳ、ＮＭＲ鉴定。
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| 关 键 词： | 布洛芬乙酯 分子筛 合成 |
Synthesis of Ibuprofen Ethyl Ester by Using Zeolite Castalyst |
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| LIU Yong ,LUO Chuan yun ,LI Lei ,XU Kun yi.Synthesis of Ibuprofen Ethyl Ester by Using Zeolite Castalyst[J].Chemical World,2000,41(2):90-92. |
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| Authors: | LIU Yong LUO Chuan yun LI Lei XU Kun yi |
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| Affiliation: | LIU Yong *1,LUO Chuan yun 2,LI Lei 1,XU Kun yi 2 |
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| Abstract: | Racemic ibuprofen ethyl ester is subject to microbial resolution in order to obtain the s(+) ibuprofen is its acid form. The racemic ester can be sucessfully prepared from racemic ibuprofen and ethanol in a ratio of 1∶1.2 with HZSM S zeolite as catalyst and benzene as carrier for water removing in azeotropic distillation. The results show that the reaction conditions are mild, the rate rapid, the product easily purified, and the yield reached 92%. The structure of the product was confirmed by IR, GC MS and NMR. |
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| Keywords: | ibuprofen ethyl ester zeolite synthesis |
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