Nucleation and growth mechanism of apatite on a bioactive and degradable ceramic/polymer composite with a thick polymer layer |
| |
Authors: | Jeong-Cheol Lee Sung Baek Cho Seung Jin Lee Sang-Hoon Rhee |
| |
Affiliation: | (1) Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Yeongeon 28, Jongno, Seoul, 110-749, Korea;(2) Mineral &; Materials Processing Division, Korea Institute of Geosciences and Mineral Resources, Kajeong 30, Yuseong, Daejeon, 305-350, Korea;(3) College of Pharmacy, Ewha Womans University, Daehyun 11-1, Seodaemun, Seoul, 120-750, Korea;(4) Department of Dental Biomaterials Science, Dental Research Institute, and BK21HLS, School of Dentistry, Seoul National University, Yeongeon 28, Jongno, Seoul, 110-749, Korea; |
| |
Abstract: | Nucleation and growth mechanism of apatite on a bioactive and degradable PLLA/SiO2–CaO composite with a thick PLLA surface layer were investigated compared to that on a bioactive but non-degradable polyurethane
(PU)/SiO2–CaO composite with a thick PU surface layer. The bioactive SiO2–CaO particles were made by a sol–gel method from tetraethyl orthosilicate and calcium nitrate tetrahydrate under acidic condition
followed by heat treatment at 600 °C for 2 h. The PLLA/SiO2–CaO and PU/SiO2–CaO composites were then prepared by a solvent casting method which resulted in thick PLLA and PU surface layers, respectively,
due to precipitation of SiO2–CaO particles during the casting process. Two composites were exposed to SBF for 1 week and this exposure led to form uniform
and complete apatite coating layer on the PLLA/SiO2–CaO composite but not on the PU/SiO2-CaO composite. These results were interpreted in terms of the degradability of the polymers. A practical implication of the
results is that a post-surface grinding or cutting processes to expose bioactive ceramics to the surface of a composite with
a thick biodegradable polymer layer is not required for providing apatite forming ability, which has been considered as one
of the pragmatic obstacles for the application as a bone grafting material. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|