Gene selection using independent variable group analysis for tumor classification |
| |
Authors: | Chun-Hou Zheng Yan-Wen Chong Hong-Qiang Wang |
| |
Affiliation: | (1) College of Information and Communication Technology, Qufu Normal University, Rizhao, Shandong, China;(2) State Key Laboratory of Information Engineering in Survey, Mapping and Remote Sensing, Wuhan University, Wuhan, China;(3) Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, China |
| |
Abstract: | Microarrays are capable of detecting the expression levels of thousands of genes simultaneously. So, gene expression data
from DNA microarray are characterized by many measured variables (genes) on only a few samples. One important application
of gene expression data is to classify the samples. In statistical terms, the very large number of predictors or variables
compared to small number of samples makes most of classical “class prediction” methods unemployable. Generally, this problem
can be avoided by selecting only the relevant features or extracting new features containing the maximal information about
the class label from the original data. In this paper, a new method for gene selection based on independent variable group
analysis is proposed. In this method, we first used t-statistics method to select a part of genes from the original data. Then, we selected the key genes from the selected genes
for tumor classification using IVGA. Finally, we used SVM to classify tumors based on the key genes selected using IVGA. To
validate the efficiency, the proposed method is applied to classify three different DNA microarray data sets. The prediction
results show that our method is efficient and feasible. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|