| 苯甲酰硫脲衍生物的合成及生物活性研究 |
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| 引用本文： | 陈帝,潘富友,杨健国. 苯甲酰硫脲衍生物的合成及生物活性研究[J]. 广东化工, 2012, 39(10): 1-2,7 |
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| 作者姓名： | 陈帝 潘富友 杨健国 |
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| 作者单位： | 1. 浙江工业大学化学与材料工程学院,浙江杭州310014 台州学院医药化工学院,浙江台州317000
2. 浙江工业大学化学与材料工程学院,浙江杭州,310014 |
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| 基金项目： | 浙江省台州市科技局科技项目(08KYl0):浙江省自然科学基金项目资助 |
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| 摘 要： | 以苯甲酸为原料，经酰化、取代等反应，合成了13个苯甲酰硫脲衍生物，通过紫外、红外和核磁共振对化合物进行了表征。生物活性采用纸张琼脂扩散法测试目标化合物对金黄色葡萄球菌、绿脓杆菌、大肠杆菌和枯草芽孢杆菌抑制活性，测试结果表明，这类化合物总体上对大肠杆菌具有较好的抑制活性。
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| 关 键 词： | 硫脲 合成 生物活性 |
Synthesis and Biological Activity of Benzoyl Thiourea Derivatives |
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| Chen Di,Pan Fuyou,Yang Jianguo. Synthesis and Biological Activity of Benzoyl Thiourea Derivatives[J]. Guangdong Chemical Industry, 2012, 39(10): 1-2,7 |
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| Authors: | Chen Di Pan Fuyou Yang Jianguo |
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| Affiliation: | 1*(1.College of Chemical Engineering and Materials Science Zhejiang University of Technology,Hangzhou 310014;2.School of Pharmaceutical and Chemical Engineering Taizhou University,Taizhou 317000,China) |
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| Abstract: | Thirteen benzoyl thiourea derivatives were synthesized from benzoic acid by acylation,substitution reaction.Their structures were characterized by UV,IR and 1H NMR.Their biological activities have been measured.The results showed that this type of compounds had certain antibacterial activity for Escherichia coli. |
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| Keywords: | thiourea synthesis: biological activity |
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