| 牛磺酸对束缚应激小鼠焦虑状态的影响 |
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| 引用本文： | 陈文,刘娇,任超,王祎,龚亚京,郭月逸. 牛磺酸对束缚应激小鼠焦虑状态的影响[J]. 中国食品学报, 2011, 11(3) |
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| 作者姓名： | 陈文 刘娇 任超 王祎 龚亚京 郭月逸 |
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| 作者单位： | 北京联合大学应用文理学院,生物活性物质与功能食品北京市重点实验室,北京,100191 |
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| 摘 要： | 为探讨牛磺酸对束缚应激小鼠自主探究活动能力的影响,将8周龄雄性BALB/C小鼠分为4组:正常对照组(C组)、应激对照组(S组)、低剂量牛磺酸组(LT组)、高剂量牛磺酸组(HT组).S、LT、HT组小鼠每日给予1 h的束缚刺激,30min后分别灌喂水和相应剂量的牛磺酸.连续6周后采用Smart小动物行为活动记录分析系统进行旷场和高架十字迷宫实验.旷场结果显示,S组小鼠在周边、中央区域的活动性分别比C组小鼠减弱10.8%(P＜0.05)和15.7%,快速移动时间百分率显著降低(P＜0.05);与S组相比较,LT和HT组小鼠在周边、中央区域的活动性都明显提升(P＜0.05),不动时间百分率下降(P＜0.05),慢速移动时间百分率明显上升(P＜0.05).高架十字迷宫结果显示,与C组相比较,S组小鼠的入臂总次数和在开臂的滞留时间都显著下降(P＜0.05),开臂移动距离百分比下降17.5%;与S组相比较,HT组小鼠在开臂的滞留时间和移动距离百分比都明显增加(P＜0.05).以上结果提示牛磺酸能够提高束缚应激小鼠的自主活动与探究能力,缓解焦虑状态.
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| 关 键 词： | 牛磺酸 旷场 高架十字迷宫 束缚应激 小鼠 |
Anxiolytic Effect of Taurine in Stressed Mice |
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| Chen Wen,Liu Jiao,Ren Chao,Wang Yi,Gong Yajing,Guo Yueyi. Anxiolytic Effect of Taurine in Stressed Mice[J]. Journal of Chinese Institute of Food Science and Technology, 2011, 11(3) |
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| Authors: | Chen Wen Liu Jiao Ren Chao Wang Yi Gong Yajing Guo Yueyi |
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| Affiliation: | Chen Wen Liu Jiao Ren Chao Wang Yi Gong Yajing Guo Yueyi (College of Arts & Science of Beijing Union University,Beijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing 100191) |
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| Abstract: | In order to study the anxiolytic effect of taurine,8-weeks-old male BALB/C mice were divided into 4 groups:control group(C),stressed group (S),low-dose taurine group (LT),and high-dose taurine group (HT) based on their body weights.The mice of S,LT and HT group were suffered restraint stress 1h a day.6 weeks later,open-field and elevated plus-maze test were determined.Open-field test results:compared with C group,fast-moving time (%) and the locomotive activity of S group in periphery and central area were ... |
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| Keywords: | taurine open-field test elevated plus-maze test restraint stress mice |
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