| 肟菌酯的合成工艺 |
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| 引用本文： | 陆翠军,刘建华,杜晓华.肟菌酯的合成工艺[J].农药,2011,50(3). |
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| 作者姓名： | 陆翠军 刘建华 杜晓华 |
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| 作者单位： | 浙江工业大学,催化加氢研究中心,杭州,310014 |
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| 摘 要： | 方法]以苯酞为主要原料,先与双(三氯甲基)碳酸酯(BTC)开环反应生成邻氯甲基苯甲酰氯,再与氰化钠反应得到邻氯甲基苯甲酰氰,甲醇酯化,然后与甲氧基胺盐酸盐肟化,最后与间三氟甲基苯乙酮肟缩合得到肟菌酯。结果]合成路线5步总收率22%。结论]该工艺简单经济,条件温和,适合工业化生产。
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| 关 键 词： | 杀菌剂 肟菌酯 邻羟甲基苯甲酸内酯 合成 |
Synthesis of Trifloxystrobin |
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| LU Cui-jun,LIU Jian-hua,DU Xiao-hua.Synthesis of Trifloxystrobin[J].Pesticides,2011,50(3). |
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| Authors: | LU Cui-jun LIU Jian-hua DU Xiao-hua |
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| Affiliation: | LU Cui-jun,LIU Jian-hua,DU Xiao-hua(Catalytic Hydrogenation Research Center,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | Methods] Trifloxystrobin was synthesized using phthalide as a main starting material,by the reactions of phthalide ring-opening with bis(trichloromethyl) carbonate to give o-chloromethylbenzoyl chloride,cyaniding to give o-chloromethylbenzoyl cyanide,esterifying with methanol,oximating with methoxyaminium chloride,and condensating with 3-(trifluoromethyl) acetopheneone oxime.Results] The total yield was 22% based on phthalide.Conclusions] This process is simple,warm and economical,which is suitable for i... |
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| Keywords: | fungicide trifloxystrobin phthalide synthesis |
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